Welcome to the Personalized Medicine Project page. I am Rui, a first year graduate student of ACCESS program, an umbrella biological program.

**Project Description**

This Project is to help doctor decide which SNPs are worth measuring for a certain type of diseases.

There are two webpages that relate to this project which can help us know more about this project:

http://www.navigenics.com/campaigns/prevention?s_kwcid=navigenics.%7C3883443815

**Goal for the quarter**

Build up a model that could help doctors choose the SNP that worthy measuring based on the prevalence and risks of the diseases.

**Weekly Schedule**

#### Week1 4/23

background learning

#### Week2 4/30

I have calculated the Var(r)(variance of risk increased by the SNP) for one single SNP based on the prevalence F and the probability of the SNP.

I problem I met was firstly I used case study way to try to find the distribution of r. It is difficult. When I switch this way to do the derivation, it's much easier. But new problem comes, the formula of Var(r) contains r itself. If I want to use this formula to real data, either I should know the r in advance or I have to estimate the r by samples. It is also like a case study then.

(1)The goal for the next step is to calculate the Var(r) for multiple SNPs, then code them in R.

I grade A for myself this week.

#### Week3 5/7

I tried to get the formula for multi-SNPs.

Assume there are 3 SNPs related to the disease:then there will be 8 situations of prevalence.

Assume SNPs are A,B,C;

The relative risk are:$\gamma_{A},\gamma_{B},\gamma_{C}$

The disease prevalence under every condition is following:

Under this condition, the formula for variance is very complex.

The plan to next step is to move to R coding for the model. Also, find a way to summary the variance for N SNPs.

I grade myself A this week.

#### Week4 5/14

After the discussion in class, I got the formula for multiple SNPs. I find to use different cases to explain the formula.

I simulate the data and create the SNP matrix using R code and calculate the expectation and variance.

I gave the presentation the first Friday.

I grade myself A- this week.

#### Week5 5/22

I prepared the presentation report for this project.

I also think out another way to measure the variance of disease prevalence.

Besides using the criteria, I think out anther way to measure, that is to use:

I grade myself A+ this week.